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1

Discovery and SAR of Novel and Selective Inhibitors of Urokinase Plasminogen Activator (uPA) with an Imidazo[1,2- a ]pyridine Scaffold

Gladysz, Rafaela, Adriaenssens, Yves, De Winter, Hans, Joossens, Jurgen, Lambeir, Anne-Marie, Augustyns, Koen, Van der Veken, Pieter

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 3.10 MB

english, 2015

2

Dynamics and ligand-induced conformational changes in human prolyl oligopeptidase analyzed by hydrogen/deuterium exchange mass spectrometry

Tsirigotaki, Alexandra, Elzen, Roos Van, Veken, Pieter Van Der, Lambeir, Anne-Marie, Economou, Anastassios

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 7.07 MB

english, 2017

3

Modeling, mutagenesis, and structural studies on the fully conserved phosphate-binding loop (Loop 8) of triosephosphate isomerase: Toward a new substrate specificity

Brian V. Norledge, Anne M. Lambeir, Ruben A. Abagyan, Antje Rottmann, Anna M. Fernandez, Vladimir V. Filimonov, Martin G. Peter, Rik K. Wierenga

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2001

Language:

english

File:

PDF, 257 KB

english, 2001

4

Development of Potent and Selective Dipeptidyl Peptidase II Inhibitors.

Kristel Senten, Pieter Van der Veken, Gunther Bal, Ingrid De Meester, Anne-Marie Lambeir, Simon Scharpe, Brigitte Bauvois, Achiel Haemers, Koen Augustyns

Journal:

Year:

2003

File:

PDF, 66 KB

2003

5

Rapid Parallel Synthesis of Dipeptide Diphenyl Phosphonate Esters as Inhibitors of Dipeptidyl Peptidases.

Kristel Senten, Liesbeth Daniels, Pieter Van der Veken, Ingrid De Meester, Anne-Marie Lambeir, Simon Scharpe, Achiel Haemers, Koen Augustyns

Journal:

Year:

2003

File:

PDF, 174 KB

2003

6

Prolylisoxazoles: Potent Inhibitors of Prolyloligopeptidase with Antitrypanosomal Activity.

Gunther Bal, Pieter Van der Veken, Dimitri Antonov, Anne-Marie Lambeir, Philippe Grellier, Simon L. Croft, Koen Augustyns, Achiel Haemers

Journal:

Year:

2003

File:

PDF, 113 KB

2003

7

A new synthetic method for proline diphenyl phosphonates

Alexander Belyaev, Marianne Borloo, Koen Augustyns, Anne-Marie Lambeir, Ingrid De Meester, Simon Scharpe, Norbert Blaton, Oswald M. Peeters, Camiel De Ranter, Achiel Haemers

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 231 KB

english, 1995

8

Kinetics of cyanide binding to chloroperoxidase in the presence of nitrate: detection of the influence of a heme-linked acid group by shift in the appa

Anne-Marie Lambeir, H. Brian Dunford, Michael A. Pickard

Journal:

Journal of Inorganic Biochemistry

Year:

1983

Language:

english

File:

PDF, 582 KB

english, 1983

9

High-pressure effect on the equilibrium and kinetics of cyanide binding to chloroperoxidase

Anne-Marie Lambeir, Karel Heremans, H.Brian Dunford

Journal:

Biophysical Chemistry

Year:

1983

Language:

english

File:

PDF, 658 KB

english, 1983

10

The role of the S1 binding site of carboxypeptidase M in substrate specificity and turn-over

Kathleen Deiteren, Georgiana Surpateanu, Kambiz Gilany, Johan L. Willemse, Dirk F. Hendriks, Koen Augustyns, Yves Laroche, Simon Scharpé, Anne-Marie Lambeir

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2007

Language:

english

File:

PDF, 1.03 MB

english, 2007

11

Dipeptidyl peptidase 9 (DPP9) from bovine testes: Identification and characterization as the short form by mass spectrometry

Véronique Dubois, Anne-Marie Lambeir, Stefaan Vandamme, Veerle Matheeussen, Yves Guisez, Simon Scharpé, Ingrid De Meester

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2010

Language:

english

File:

PDF, 958 KB

english, 2010

12

Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines

Anna Soroka, Pieter Van der Veken, Ingrid De Meester, Anne-Marie Lambeir, Marie-Berthe Maes, Simon Scharpé, Achiel Haemers, Koen Augustyns

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 101 KB

english, 2006

13

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: Isoindoline containing inhibitors

Sebastiaan Van Goethem, Pieter Van der Veken, Véronique Dubois, Anna Soroka, Anne-Marie Lambeir, Xin Chen, Achiel Haemers, Simon Scharpé, Ingrid De Meester, Koen Augustyns

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 326 KB

english, 2008

14

Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: Identification of dipeptide derived leads

Pieter Van der Veken, Ingrid De Meester, Véronique Dubois, Anna Soroka, Sebastiaan Van Goethem, Marie-Berthe Maes, Inger Brandt, Anne-Marie Lambeir, Xin Chen, Achiel Haemers, Simon Scharpé, Koen Augus

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 244 KB

english, 2008

15

Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group

Katie Amssoms, Sandra L Oza, Esteban Ravaschino, Abdellah Yamani, Anne-Marie Lambeir, Padinchare Rajan, Gunther Bal, Juan Bautista Rodriguez, Alan H Fairlamb, Koen Augustyns, Achiel Haemers

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 115 KB

english, 2002

16

Development of potent and selective dipeptidyl peptidase II inhibitors

Kristel Senten, Pieter Van der Veken, Gunther Bal, Ingrid De Meester, Anne-Marie Lambeir, Simon Scharpé, Brigitte Bauvois, Achiel Haemers, Koen Augustyns

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 91 KB

english, 2002

17

Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity

Gunther Bal, Pieter Van der Veken, Dimitri Antonov, Anne-Marie Lambeir, Philippe Grellier, Simon L. Croft, Koen Augustyns, Achiel Haemers

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 158 KB

english, 2003

18

Structural determinants for ligand binding and catalysis of triosephosphate isomerase

Inari Kursula, Sanna Partanen, Anne-Marie Lambeir, Dmitry M. Antonov, Koen Augustyns, Rik K. Wierenga

Journal:

Year:

2001

Language:

english

File:

PDF, 584 KB

english, 2001

19

The ionization of a buried glutamic acid is thermodynamically linked to the stability of Leishmania mexicana triose phosphate isomerase

Anne-Marie Lambeir, Jan Backmann, Javier Ruiz-Sanz, Vladimir Filimonov, Jens Erik Nielsen, Inari Kursula, Brian V. Norledge, Rik K. Wierenga

Journal:

Year:

2000

Language:

english

File:

PDF, 690 KB

english, 2000

20

Molecular characterization of dipeptidyl peptidase activity in serum : Soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides

Christine Durinx, Anne-Marie Lambeir, Eugène Bosmans, Jean-Bernard Falmagne, Raf Berghmans, Achiel Haemers, Simon Scharpé, Ingrid De Meester

Journal:

Year:

2000

Language:

english

File:

PDF, 400 KB

english, 2000

21

The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes

Martin E. M. Noble, Rik K. Wierenga, Anne-Marie Lambeir, Fred R. Opperdoes, Andy-Mark W. H. Thunnissen, Kor H. Kalk, Hillie Groendijk, Wim G. J. Hol

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1991

Language:

english

File:

PDF, 1.63 MB

english, 1991

22

Synthesis and evaluation of azaproline peptides as potential inhibitors of dipeptidyl peptidase IV and prolyl oligopeptidase

Marianne Borloo, Koen Augustyns, Alexander Belyaev, Ingrid Meester, Anne-Marie Lambeir, Filip Goossens, Willy Bollaert, Padinchare Rajan, Simon Scharpé, Achiel Haemers

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1995

Language:

english

File:

PDF, 264 KB

english, 1995

23

Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: Substitution of the glycine part

Katie Amssoms, Sandra L Oza, Koen Augustyns, Abdellah Yamani, Anne-Marie Lambeir, Gunther Bal, Pieter Van der Veken, Alan H Fairlamb, Achiel Haemers

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 95 KB

english, 2002

24

Dipeptidyl-Peptidase IV from Bench to Bedside: An Update on Structural Properties, Functions, and Clinical Aspects of the Enzyme DPP IV

Lambeir, Anne-Marie, Durinx, Christine, Scharpé, Simon, De Meester, Ingrid

Journal:

Critical Reviews in Clinical Laboratory Sciences

Year:

2003

Language:

english

File:

PDF, 4.73 MB

english, 2003

25

Structure−Activity Relationship of Diaryl Phosphonate Esters as Potent Irreversible Dipeptidyl Peptidase IV Inhibitors

Belyaev, Alexander, Zhang, Xuemei, Augustyns, Koen, Lambeir, Anne-Marie, De Meester, Ingrid, Vedernikova, Irina, Scharpé, Simon, Haemers, Achiel

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 223 KB

english, 1999

26

Dipeptidyl Peptidase IV (DPPIV/CD26)-Based Prodrugs of Hydroxy-Containing Drugs

Dr. Alberto Diez-Torrubia, Dr. Silvia Cabrera, Dr. Anne-Marie Lambeir, Prof. Jan Balzarini, Prof. María-José Camarasa, Dr. Sonsoles Velázquez

Journal:

Year:

2012

Language:

english

File:

PDF, 504 KB

english, 2012

27

Use of immobilized adenosine deaminase (EC 3.5.4.4) for the rapid purification of native human CD26/dipeptidyl peptidase IV (EC 3.4.14.5)

Ingrid De Meester, Greet Vanhoof, Anne-Marie Lambeir, Simon Scharpé

Journal:

Journal of Immunological Methods

Year:

1996

Language:

english

File:

PDF, 429 KB

english, 1996

28

Demonstration of glycosomes (microbodies) in the bodonid flagellate Trypanoplasma borelli (protozoa, kinetoplastida)

Fred R. Opperdoes, Eva Nohynkova, Emile Van Schaftingen, Anne-Marie Lambeir, Marten Veenhuis, Joris Van Roy

Journal:

Molecular and Biochemical Parasitology

Year:

1988

Language:

english

File:

PDF, 1019 KB

english, 1988

29

Kinetics of cyanide binding by half-reduced Pseudomonas cytochrome c peroxidase

Marjaana Rönnberg, Anne-Marie Lambeir, Nils Ellfolk, H.Brian Dunford

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1985

Language:

english

File:

PDF, 393 KB

english, 1985

30

The formation and decay of the oxyferrous forms of the cytochromes P-450 isolated from Rhizobium japonicum. Rapid spectral scan and stopped flow studies

Anne-Marie Lambeir, Cyril A. Appleby, H.Brian Dunford

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1985

Language:

english

File:

PDF, 531 KB

english, 1985

31

Rapid spectral scan and stopped-flow studies of carbon monoxide binding to bovine adrenocortical cytochrome P-450scc

Mohammed A. Kashem, Anne-Marie Lambeir, H.Brian Dunford

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1987

Language:

english

File:

PDF, 404 KB

english, 1987

32

Efficient conversion of tetrapeptide-based TSAO prodrugs to the parent drug by dipeptidyl-peptidase IV (DPPIV/CD26)

Carlos García-Aparicio, Alberto Diez-Torrubia, Jan Balzarini, Anne-Marie Lambeir, Sonsoles Velázquez, María-José Camarasa

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 730 KB

english, 2007

33

Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile)

Inger Brandt, Jurgen Joossens, Xin Chen, Marie-Berthe Maes, Simon Scharpé, Ingrid De Meester, Anne-Marie Lambeir

Journal:

Biochemical Pharmacology

Year:

2005

Language:

english

File:

PDF, 342 KB

english, 2005

34

Dipeptidyl peptidase II and leukocyte cell death

Marie-Berthe Maes, Wim Martinet, Dorien M. Schrijvers, Pieter Van der Veken, Guido R.Y. De Meyer, Koen Augustyns, Anne-Marie Lambeir, Simon Scharpé, Ingrid De Meester

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 506 KB

english, 2006

35

DPP4 inhibitors for diabetes—What next?

Anne-Marie Lambeir, Simon Scharpé, Ingrid De Meester

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 174 KB

english, 2008

36

In vivo profiling of DPP4 inhibitors reveals alterations in collagen metabolism and accumulation of an amyloid peptide in rat plasma

Marco M. Jost, Jens Lamerz, Harald Tammen, Christoph Menzel, Ingrid De Meester, Anne-Marie Lambeir, Koen Augustyns, Simon Scharpé, Hans Dieter Zucht, Horst Rose, Michael Jürgens, Peter Schulz-Knappe,

Journal:

Biochemical Pharmacology

Year:

2009

Language:

english

File:

PDF, 535 KB

english, 2009

37

Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA)

Muthusamy Venkatraj, Jonas Messagie, Jurgen Joossens, Anne-Marie Lambeir, Achiel Haemers, Pieter Van der Veken, Koen Augustyns

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 599 KB

english, 2012

38

Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity

Oxana Ryabtsova, Koen Jansen, Sebastiaan Van Goethem, Jurgen Joossens, Jonathan D. Cheng, Anne-Marie Lambeir, Ingrid De Meester, Koen Augustyns, Pieter Van der Veken

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 395 KB

english, 2012

39

The dipeptidyl peptidase IV (CD26, EC 3.4.14.5) inhibitor vildagliptin is a potent antihyperalgesic in rats by promoting endomorphin-2 generation in the spinal cord

Kornél Király, Anne-Marie Lambeir, Judit Szalai, Apolka Szentirmay, Walter Luyten, István Barna, Zita Puskár, Márk Kozsurek, András Z. Rónai

Journal:

European Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 449 KB

english, 2011

40

In situ prolyl oligopeptidase activity assay in neural cell cultures

Linda Klimaviciusa, Rajeev Kumar Jain, Külli Jaako, Roos Van Elzen, Melanie Gerard, Pieter van Der Veken, Anne-Marie Lambeir, Alexander Zharkovsky

Journal:

Journal of Neuroscience Methods

Year:

2012

Language:

english

File:

PDF, 592 KB

english, 2012

41

A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro

Anne-Marie Lambeir, Paul Proost, Simon Scharpé, Ingrid De Meester

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 140 KB

english, 2002

42

A prediction of DPP IV/CD26 domain structure from a physico-chemical investigation of dipeptidyl peptidase IV (CD26) from human seminal plasma

Anne-Marie Lambeir, José Fernando Dı́az Pereira, Pablo Chacón, Geert Vermeulen, Karel Heremans, Bart Devreese, Jozef Van Beeumen, Ingrid De Meester, Simon Scharpé

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1997

Language:

english

File:

PDF, 1.00 MB

english, 1997

43

Oxygen binding to dithionite-reduced chloroperoxidase

Anne-Marie LAMBEIR, H. Brian DUNFORD

Journal:

Year:

1985

Language:

english

File:

PDF, 383 KB

english, 1985

44

Rapid-scan stopped-flow studies of the pH dependence of the reaction between mercuric reductase and NADPH

Lena SAHLMAN, Anne-Marie LAMBEIR, Sven LINDSKOG

Journal:

Year:

1986

Language:

english

File:

PDF, 922 KB

english, 1986

45

Glyceraldehyde-phosphate dehydrogenase from Trypanosoma brucei : Comparison of the glycosomal and cytosolic isoenzymes

Onno MISSET, Jozef VAN BEEUMEN, Anne-Marie LAMBEIR, Rob VAN DER MEER, Fred R. OPPERDOES

Journal:

Year:

1987

Language:

english

File:

PDF, 724 KB

english, 1987

46

Kinetics of the oxidation of ascorbic acid, ferrocyanide and p-phenolsulfonic acid by chloroperoxidase compounds I and II

Anne-Marie LAMBEIR, H. Brian DUNFORD, Michael A. PICKARD

Journal:

Year:

1987

Language:

english

File:

PDF, 574 KB

english, 1987

47

Kinetic properties of triose-phosphate isomerase from Trypanosoma brucei brucei : A comparison with the rabbit muscle and yeast enzymes

Anne-Marie LAMBEIR, Fred R. OPPERDOES, Rik K. WIERENGA

Journal:

Year:

1987

Language:

english

File:

PDF, 608 KB

english, 1987

48

Glucosephosphate isomerase from Trypanosoma brucei : Cloning and characterization of the gene and analysis of the enzyme

Martine MARCHAND, Ulco KOOYSTRA, Rik K. WIERENGA, Anne-Marie LAMBEIR, Jos Van BEEUMEN, Fred R. OPPERDOES, Paul A. M. MICHELS

Journal:

Year:

1989

Language:

english

File:

PDF, 1.23 MB

english, 1989

49

Kinetics of the reaction of compound II of horseradish peroxidase with hydrogen peroxide to form compound III

Suara A. ADEDIRAN, Anne-Marie LAMBEIR

Journal:

Year:

1989

Language:

english

File:

PDF, 625 KB

english, 1989

50

The cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei : Kinetic properties and comparison with homologous enzymes

Anne-Marie LAMBEIR, Ann M. LOISEAU, Douglas A. KUNTZ, Frederic M. VELLIEUX, Paul A. M. MICHELS, F. R. OPPERDOES

Journal:

Year:

1991

Language:

english

File:

PDF, 750 KB

english, 1991